इसे छोड़कर सामग्री पर बढ़ने के लिए मुख्य नेविगेशन पर जाएं फ़ुटर पर जाएँ

कैप्टन श्रीनिवास मूर्ति केंद्रीय आयुर्वेद अनुसंधान संस्थान, चेन्नई

Captain Srinivasa Murthy Central Ayurveda Research Institute (CSMCARI), Chennai, Tamil Nadu

1.About the Institute

Captain Srinivasa Murthy Central Ayurveda Research Institute (CSMCARI), Chennai is a prominent institution under the Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of Ayush, Government of India. It is dedicated to advancing research in Ayurveda and promoting indigenous systems of medicine.

The institute was named after Captain Dr. G. Srinivasa Murthy, a legendary figure in Indian medicine. His disciple, Dr V. Narayana Swamy, founded the institute, initially named Captain Srinivasa Murthy Drug Research Institute for Ayurveda (CSMDRIA) in the year 1963 in IMPCOPS, Chennai, with a motive to study the phytochemical aspects of medicinal plants used in Indian Systems of Medicine. Later, in August 1972, the erstwhile Central Council for Research in Indian Medicine and Homoeopathy (CCRIM&H) took over this Institute. In March 1978, CCRIMH was bifurcated into two separate councils, and this Institute became a part of the Central Council for Research in Ayurveda and Siddha (CCRAS). Subsequently, in September 2010, the Central Council for Research in Ayurveda and Siddha (CCRAS) was bifurcated into two individual councils, Central Council for Research in Ayurvedic Sciences (CCRAS) and Central Council for Research in Siddha (CCRS). Since then, the institute has come under CCRAS. From 2021 onwards, the institute was known as Captain Srinivasa Murthy Central Ayurveda Research Institute (CSMCARI).

1.2. Vision and Mission

  1. To promote research, drug standardisation and training in the field of Ayurveda and traditional medicine.
  2. To establish Pharmacopoeial monographs and technical dossiers for the Indian Systems of Medicine
  3. To maintain excellence in testing services as per national/international standards.

1.3. Eponymy: Legacy and inspiration behind our name

Vaidya Ratna Captain Dr. G. Srinivasa Murthy (1887–1962)

Captain Dr. Gorur Srinivasa Murthy was a visionary physician, scholar, and reformer whose pioneering efforts laid the foundation for current scientific study of Indian systems of medicine. Born in Haltore village in Hassan District, he was an outstanding student who earned degrees in Arts, Medicine, Law, and Sanitary Engineering, winning the Chipperfield and Johnstone Gold Medals for general proficiency. Despite no formal training in Sanskrit, he delivered the Presidential Address of the All India Ayurvedic Congress (1924) in proficient Sanskrit. It was a proof to his erudition and devotion to India’s heritage.

After joining the State Medical Service in 1912 – where he served in various capacities – and serving as a Captain in the Indian Medical Service during World War I – where he offered his services in many military hospitals across India -, he combined discipline with deep compassion for healing. His collaboration with the Usman Committee, formed to recognize and encourage indigenous medical systems, led to his seminal work “The Science and Art of Indian Medicine”, which inspired the establishment of the School of Indian Medicine at Kilpauk in 1925, where he served as the first Principal and founded the Integral System – a system that integrate the strengths of both Ayurveda and Allopathy. As a dedicated teacher and institution-builder, he trained generations of practitioners. The School of Indian Medicine conferred him a Diploma in LIM (Licentiate in Indian Medicine) and a Post Graduate degree in Indian Medicine (HPIM – Higher Proficiency in Indian Medicine). A Theosophist influenced by Dr. Annie Besant, he later directed the Adyar Library (1934–1954), elevating it into a premier institution. After retirement, he founded IMPCOPS (Indian Medical Practitioners Co-operative Pharmacy & Stores) in 1944 to ensure the production of authentic Ayurvedic, Siddha, and Unani medicines under hygienic and standardized conditions, which carries his legacy even today.

Honoured with the title Vaidya Ratna during King’s Birthday Honors of 1932, Captain Murthy embodied purity, simplicity, and selfless service. His disciple Dr. V. Narayanaswamy founded this institute in 1963 to perpetuate his ideals. His life remains a shining example of dedication, leadership, and scholarship.  We offer our respects to the memory of an extraordinary individual and a dedicated Karmayogi.

1.4. Institute history in brief

Captain Srinivasa Murthy Central Ayurveda Research Institute (CSMCARI), Chennai, traces its origin to 1963 when it was established as the Captain Srinivasa Murthy Drug Research Institute for Ayurveda (CSMDRIA) by Dr. V. Narayanaswamy, a student and colleague of Dr. G. Srinivasa Murthy, a legendary figure in Indian medicine. Supported by Dr. C. Dwarakanath, then Advisor (ISM), Ministry of Health, and with infrastructural assistance from Indian Medical Practitioners’ Co-operative Pharmacy and Stores Limited (IMPCOPS), the institute was inaugurated on 10 January 1963 by the Union Health Minister, Dr. Sushila Nayar. Initially functioning within IMPCOPS, the institute focused on research in phytochemistry and pharmacognosy under Dr. Narayanaswamy’s leadership, studying regionally significant medicinal plants. The Department of Biochemistry was added in 1967, marking the start of vigorous phytochemical studies that led to the development of Imbural tablets, an antitubercular and haemostatic formulation.

A standardization Unit for Ayurveda was established in 1970, leading to the standardisation of 446 formulations from the Ayurvedic Formulary of India. In 1972, the institute was brought under the Central Council for Research in Indian Medicine and Homoeopathy (now CCRAS). In 1974, a pharmacy for Ayurveda and Siddha preparations was added, and in 1977, the institute was affiliated with the University of Madras for Ph.D. research. Under Dr. K.K. Purushothaman’s leadership (1972–1988), the institute published over 150 research papers. To accommodate its growing research activities, the Tamil Nadu Government allotted two floors (9600 sq. ft.) in the Arignar Anna Hospital Campus, Chennai, where the institute was shifted in 1977.

Later, a separate land measuring 7200 sq. ft. was acquired for expansion on the recommendation of the Director of Indian Medicine, Government of Tamil Nadu. A new building was constructed on this land, and in 2013, the institute moved into its present premises within the Arignar Anna Government Hospital of Indian Medicine campus, Arumbakkam, Chennai.

The institute underwent several transformations. It was renamed as Captain Srinivasa Murthy Research Institute for Ayurveda and Siddha Drug Development (2009), later as Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute (2017), and finally as Captain Srinivasa Murthy Central Ayurveda Research Institute (CSMCARI). Now functioning under the Ministry of Ayush, Government of India, the institute has six departments: Ayurveda, Pharmacology, Chemistry, Biochemistry, Microbiology, and Botany/ Pharmacognosy. The institute continues its legacy of six decades as a pioneering institute for Ayurvedic drug research and academic excellence.

1.5. Organizational Chart

1.6. Services Offered

The institute offers a comprehensive suite of services that caters to both regulatory requirements and academic training. These services are designed to support manufacturers, researchers, students, etc., engaged in the development and validation of ASU drugs.

1. Testing and evaluation of ASU Drugs

a. Shelf-life and stability studies: These assessments determine the optimal storage conditions and expiration timelines of ASU formulations, ensuring consumer safety and product reliability.

b. Botanical and pharmacognostic identification and authentication: The institute conducts microscopic and macroscopic evaluations of fresh/ dry/ mounted plant specimens and raw drugs to verify botanical identity for authentication of the plant and to detect adulteration. Herbarium vouchers can also be deposited in the institute regional herbarium.

c. Physicochemical analysis: A wide range of tests are performed to evaluate parameters such as pH, moisture content, ash values, extractive values, and other quality indicators.

d. Safety and efficacy studies: Preclinical evaluations are carried out using validated models to assess the therapeutic potential and toxicological profile of ASU drugs.

e. Microbial testing: These include assays for microbial load, heavy metals, aflatoxins, and other contaminants, ensuring compliance with pharmacopoeial standards.

2. Academic and skill development programs

a. Internship Training: The institute offers a well-structured Internship Training Programme aimed at equipping undergraduate and postgraduate students with practical exposure to traditional medicine research and laboratory practices. The programme is delivered in two formats: a short-term 15-day training module, one month and 3-month training module. These modules are designed for students seeking a concise yet intensive introduction to ASU drug testing, covering multiple disciplines.

b. Project-based internship: The project-based internship, typically spanning 4 to 8 weeks, is tailored for students undertaking academic research or fulfilling curriculum-based project requirements. Interns engage in supervised research activities such as shelf-life studies, microbial load analysis, pharmacological studies and instrument-based evaluations. They are encouraged to formulate research questions, collect and interpret data, and present their findings through structured reports and presentations.

c. Hands-on training on sophisticated instruments: The institute also offers specialized training modules on advanced analytical instruments such as High-Performance Liquid Chromatography (HPLC), Gas Chromatography- Mass Spectrometer (GC-MS), UV-Visible Spectrophotometry, Fourier Transform – Infra red (FT-IR), Induction Coupled Plasma – Organic Emission Spectrophotometer (ICP-OES), Atomic Absorption Spectrophotometer (AAS), Flame Photometer, High Performance Thin Layer Chromatography (HPTLC), Arc HPLC, RT- PCR, Thermal Cyclers (PCR), Hematology analyser, Clinical Chemistry auto analyser, ELISA Reader, Multimode reader and others.

2. Human Resources

Dr. S. Chitra – Assistant Director-In-Charge
Technical
Ayurveda/ Pharmacy
Dr. Soumya MC – Research Officer
Pharmacology
Dr. R. Arunadevi – Research Officer
Ms. N. Monika – Assistant Research Officer
Smt. M. Thenmozhi – Assistant Research Officer
Smt. K.C. Haritha Yadav – Assistant Research Officer
रसायन विज्ञान
Dr. Vinod Kumar Thallada – Research Officer
Dr. Kousik Ghosh – Research Officer
Smt. Maheswari B – Research Assistant
Shri V. Naresh – Research Assistant
Smt. C. Shakila – Laboratory Attendant
सूक्ष्म जीव विज्ञान
Dr Swamy C.T – Research Officer (Microbiology)
Shri Ravi Prakash Shaliwal – Assistant Research Officer (Biotechnology)
Shri R. Raghul Gandhi – Laboratory Attendant
Botany/ Pharmacognosy
Dr. Vishnu Walsan A – Research Officer
Mr. C. Prem Kumar – Assistant Research Officer
Dr. Akansha Pandey – Research Assistant
Biochemistry
Dr Anshu Wali – Research Assistant
प्रशासन
Smt. E. Nagalakshmi – Private Secretary
Shri Balaji B. – Upper Division Clerk
Support Staff
Shri R. Loganathan – Multi Tasking Staff

Employee details                    : Annexure I

Biodata of officers and staff   : Annexure II

3. Communication & Publicity

Suo Moto Disclosures             : Annexure III

Hindi Magazine                     : Annexure IV

4. Research & Development:

In its early stages, the institute focused on three key research areas: cancer research, family welfare programs, and malaria research. Several anti-cancerous principles have been isolated from medicinal plants, such as solamarine from Solanum trilobatum and plumbagin from Plumbago zeylanica.

At present, the institute is actively engaged in Ayurvedic research in various disciplines across three broad areas – Medicinal Plant Research, Drug Standardization Research and Pharmacology Research. The focus is on the development and scientific validation of Ayurvedic formulations and single-plant-based medicines.

More than 600 research papers have been published in various national and international journals, 15 book chapters and about 154 scientific papers have been presented in various scientific seminars, conferences and symposia. The work carried out in CSMCARI has been included in the various publications of the Department of AYUSH and ICMR. Research activities confer various departments have been described below. The status of ongoing and completed projects (IMR/EMR) mentioned pertains to last 10 years.

Publication List           : Annexure V

4.1. Medicinal Plant Research

Medicinal Plant Research (MPR) at CSMCARI, Chennai, is executed by two departments – Botany/ Pharmacognosy and Pharmacy.

Department of Botany/ Pharmacognosy

Department of Botany/ Pharmacognosy conducts research and provides testing services in various areas related to the identification, authentication, and development of quality standards of medicinal plants and raw drugs used in Ayurveda.

To date, the department has contributed around 50 research publications in national and international journals and successfully completed seven intramural research projects. Four intramural research projects are currently ongoing, focusing on ethnobotany of Kolli and Pachamalai hills, and development of quality standards of drugs used in Ayurveda and traditional medicine. Monographs prepared by the department have been incorporated into the Ayurvedic Pharmacopoeia of India (API) and the Ayurvedic Formulary of India (AFI). The department has developed and published 15 powder monographs in API Part-I, Vol. VIII (2011), 8 Comprehensive Technical Dossiers on single drugs, 117 monographs for Quality Standards of Indian Medicinal Plants (published by ICMR). The department has also carried out studies on several compound formulations including Nimbadi Kwath Curna, Trikatu Curna, Sunthi Guggulu, Gomutra Haritaki, AYUSH-A, AYUSH-D, AYUSH Herbal Tea, and AYUSH M3.

The department also hosts an NABL-accredited laboratory which provides testing services under four parameters: macroscopic identification, sectional studies, powder microscopy, and taxonomic identification of Ayurvedic drugs. Since 2008, the department has been maintaining NABL Accreditation as per ISO/IEC 17025: 2017, adhering to NABL Standards. It is also recognized as a Drug Testing Laboratory (DTL) by the State Government of Tamil Nadu.

Captain Srinivasa Murthy Herbarium (CSMH), the regional herbarium under the department, which houses accessions dating back to 1960, is internationally indexed under Index Herbariorum of New York Botanical Garden, with the acronym “CSMH”. The department provides internships, training, and assistance for dissertations and research projects of post-graduate students. The department is equipped with sophisticated instruments, including High-Performance Liquid Chromatography (HPLC), High-Performance Thin Layer Chromatography (HPTLC), deep freezer (-80°C), a Trinocular compound microscope with CMOS camera and drawing tube attachment, a stereo zoom microscope and a flatbed herbarium scanner (1600 dpi).

Ongoing ProjectsCompleted Projects
1. Development of Quality standards for Useful Parts of Selected Medicinal Plants of Ayurveda (IPS0033)

 2. Development of Quality Standards of Elsholtzia Species and assessment of Efficacy in Gastric Inflammatory Conditions (CPS0002)
 3. Medico-Ethnobotanical Surveys in Kolli Malai and Pacha Malai and preparation of Monographs. (IBO0066)    
 4. Development of a Rapid and Cost-Effective Primer-Based Tool for Correct Species Determination of Some Commonly Traded Herbal Drugs. (IBO0080)
1. Developing Pharmacognostical Standards for some Ambiguous Ayurvedic Drugs (Sandigdha Dravyas) appearing in the Ayurvedic Formularies, Parts I to III. (IPS0013)

 2.Pharmacognostical Evaluation of Medicinal Plants cited in Ayurvedic Formulary of India excluding the plants mentioned in Ayurvedic Pharmacopoeia of India- Part –I

 3.Pharmacognostical Evaluation of Medicinal Plants cited in Ayurvedic Formulary of India excluding the plants mentioned in Ayurvedic Pharmacopoeia of India- Part –II. (IPS0014)

 4 .Photographic Atlas on Macro-microscopic Characteristics of Medicinal Plants Listed in Ayurvedic Pharmacopoeia of India, Part-I, Volume – II. (IPS0019)

 5.Development of drug Master file and dossier on Fruits of Emblica officinalis (Farm: Phyllanthaceae) for Important Promising Medicinal Plants Based on Leads from Ayurveda & Contemporary Research. (IPS0027)

 6.Development of Quality Standards of Selected Extra-pharmacopoeial Drugs (Anukta Dravyas) Used in Local Health Traditions Collected from Different Regions of India. (IPS0028)

 7.Anthology of Pharmacognostical Research Outcomes of CCRAS on Selected Medicinal Plants of Ayurveda.   8. Development and Digitalization of Authentic Ayurvedic Raw Drugs and Herbarium for the Medicinal Plants Appearing in Ayurvedic Formularies of India in Mandatory Drug Testing Laboratories of CCRAS. (IPS0027)

Department of Pharmacy/ Ayurveda

The pharmacy department of CSMCARI possesses a pharmacy section and a machinery room. This department is actively engaged in Developing Quality Standards for crude drugs and in developing Standard Operating Procedures for various Ayurvedic formulations. The pharmacy section is equipped with a Pill-making machine, a distillation unit, an End-runner mill, a fermentation vessel, a Tray drier, a Laboratory Blender, a Membrane filter with a vacuum pump, and a Capsule-filling machine. The machinery room is installed with Mini pulveriser (for making curnas), a disintegrator (for making kasayam powders) and a jaw-crusher (for disintegrating very hard plant parts like heart-wood, root and bark).

Ayurvedic drugs are mainly based on plants and plant-based products, besides animal products, metals/minerals and marine origin drugs (Sudha-varga drugs). In the Ayurvedic Drug manufacturing industry, there is a significant increase in information on Ayurvedic drugs and identification of constituents of drugs, parts used, method of preparation and standardisation of products. At the same time, new problems have also emerged in this sector, like non-availability of some of the constituent drugs, especially the root and bark of several plants., increase in demand of Ayurvedic drugs leading to substitution/adulteration, imposition of new laws to protect the environment as well as various plant species and formulations like Curnas (Powders), Bhasmas (metallic preparations), Asavas, Aristas (Alcoholic preparations), according to classical methods. Realising these problems in the supply of raw material, there is a need to facilitate the availability of raw drugs, which are authentic and contain the essential components as required under the Pharmacopoeial Standards. Keeping these facts in view since inception to 2023, the Pharmacy department is working in this research area and has taken up steps to develop Quality standards for plants, animals and mineral origin drugs and develop Standard Operating Procedures for processing to improve the quality of the final product.

The department is also concentrating on ethno-medicinal survey studies (2014-2017). Currently working on developing quality standards for extra-pharmacopeial drugs and Arka formulations and involved in organising medical camps at various places. The department is also acting as the facilitating centre to other departments of the institute, in selecting suitable drugs for research projects. So far, SOPs have been developed for 65 Ayurvedic formulations.

Ongoing ProjectCompleted Project
1. A Cross-sectional Survey to study the distribution pattern of different prakriti types across India – A multi centric study
2. Implementation and Evaluation of a Health Care Model Using Structured Yoga and Lifestyle Interventions for Wellness Promotion and Chronic Disease Risk Reduction: A Health Systems Research Study
1. Ethno-medicinal Survey of Plants Used in Various Diseases by Tribe of Thandarai, Chengalpattu, Kancheepuram District, Tamilnadu 2. Developing Quality Standards for selected Extra-pharmacopoeial drugs collected from Irula tribes of Thandarai, Kancheepuram District, Tamilnadu
3. Documentation of Life Profiles of Luminaries of Ayurveda – Vaidyaratna Captain G Srinivasa Murthy
4. Documentation of Life Profiles of Luminaries of Ayurveda – Ms Savita Satakopan
5. Documentation of Life Profiles of Admirable Personalities to Transform Ayurveda (APTA)’ – Padmashri Dr. V. Narayanaswamy
6. Documentation of Life Profiles of Luminaries of Ayurveda – Vaidyaratna N Rama Varier
7. Documentation of Life Profiles of Admirable Personalities to Transform Ayurveda (APTA)’ – Aryavaidyan P V Raghava Varier
8. Developing Quality Standards for selected Arka Formulations

4.2. Drug Standardization Research

Drug Standardisation Unit was established in the year 1979 as a separate project for the Standardization of Siddha drugs. This was consequent to the bifurcation of Central Council for Research in Indian Medicine & Homeopathy into separate Councils in March 1978. Later this unit got merged with the Chemistry department of CSMCARI Chennai.

Department of Chemistry

The department comprises two sections: Analytical and Phytochemical. The Analytical section focuses on standardizing Ayurvedic drugs based on pharmacopoeial parameters. It has completed 446 formulations in Part I and Part II of the Ayurvedic Formulary of India. Standards for individual ingredients used in compound preparations are also being developed. The Phytochemical section investigates the chemistry of medicinal plants through extraction, fractionation, and isolation of known and novel compounds, followed by structural identification and biological screening. Notable bioactive compounds include Solamarine, Gangetin, Vicolides A–D, Physalin D, Arbortristosides A & B, Echitamine chloride, Plumbagin, Cryptanoside-A, Oleanolic acid D-glycoside, and Ruberythric acid. A key achievement is the isolation of an alkaloidal glucoside from Solanum trilobatum, patented and under commercial development for use as a cancer treatment adjuvant.

Since 2008, the department has been maintaining NABL Accreditation as per ISO/IEC 17025: 2017, adheres to NABL Standards. It is also recognized as a Drug Testing Laboratory by the State Government of Tamil Nadu to carry out the drug testing for industries/academic institutes/laboratories etc. In addition to sample testing, the department has been conducting cutting-edge research in the Indian system of medicine, especially, in Ayurvedic sciences. The department has equipped with sophisticated analytical instruments like GC-MS, ICP-OES, HPLC, HPTLC, AAS, Flash chromatography, Flame photometry, UV-Vis spectrophotometer, FT-IR, Rotary evaporator, milli-Q water system, Polarimeter, and other minor equipment. The Department mainly carries out preliminary phytochemical and physicochemical analysis, isolation of chemical markers and their elucidation, development of TLC/HPTLC fingerprint profile, estimation of markers and phytochemicals in single drug as well as compound formulation of herbal drugs, estimation of heavy metals, and identification of adulterants using analytical techniques.

Ongoing projectsCompleted Projects
1.Phytochemical investigation of hydro-alcoholic extractives with different ratios of selected Kvatha formulations (ICH077)

2.Development of quality standards & SOP with markers-based analysis and shelf-life study of four medicinally important classical Ayurvedic formulations (ICH069)

3.Development of quality standards, Estimation of markers, and shelf-life studies of Kvatha churna formulations (ICH068)

4. Comparative Phytochemical Evaluation of Ht.Wd with small branches, leaves, and stem bark of common medicinal plants used in Ayurveda (ICH078)

5.Development of Quality Standards, Estimation of Markers and accelerated shelf-life studies of Guducyadi, Caturbhadra and Amrtottara kvatha churna formulations (ICH079)

6. Unraveling the Phytochemical Landscape of Selected Ayurvedic Tailas Through Advanced Chromatographic Profiling  
7. Chemical Profiling of Seven Ayurvedic Plant Drugs (Stem bark/Root and Small branches/Aerial parts) by HPLC/GC-Ms/LC-MS and other related   techniques

8. Development of Standards for Musk-Raw Drug of Animal Origin used in ASU Drugs

9.Effect of Shodhan procedures on Chemical profiling of Ayurvedic drugs of plant origin (Visa Drvya) mentioned under Schedule E-1 of D&C Act

10.Qualitative and Quantitative analysis of markers/PRS & Shelf-life study of Ayush -D Tablet and Ayush PE eye drop formulations (prepared trial drugs)

11.Qualitative and Quantitative analysis of Markers/PRS & Shelf-life studies of Carctol – S Capsules, Ayush-SL Tablets and Ksharasutra formulations (prepared trial drugs)

12.Development of quality standards of Indian Indigenous medicinal plants and preparation of monographs thereon

13.Qualitative Authentication of selected market samples of crude drugs available in various markets of India

14. To establish the best procurement time for certain herbs by analyzing the seasonal variation in bioactive secondary metabolites with qualitative HPLC

15.Evaluation of Seasonal and Geographical Variation on Phytoconstituents/Marker Compounds in Selected Ayurvedic Medicinal Plants

16.Estimation of Calcium and Trace Minerals & Metals in Sudhavarga drugs of Ayurveda

17.Isolation of marker compounds from Ayurvedic Plants and Development of Marker Compound Library

18.Pharmaceutical Development and Standards for Formulation AYUSH-64

19.Nutritional profiling, Estimation of marker of Balya drugs

20.Isolation of Marker Compounds and Development of Marker Compound Library from four Selected Ayurvedic Medicinal Plants (Kancanara, Asthisrnkhala, Puskara & Lajjalu)


21.Evaluation of Seasonal and Geographical variation of phytoconstituents/marker compounds in selected Ayurvedic Medicinal Plants

4.3. Pharmacological Research

Pharmacological research at CSMCARI, Chennai, is executed by pharmacology, biochemistry and microbiology departments.

Department of Pharmacology

Ongoing ProjectsCompleted Projects
1.Cardioprotective Effect of Pushkara Guggulu on Experimentally Induced Myocardial Infarction in Rats

 2. Development of Madhuca longifolia (Flower) based food recipe (Product development) and its nutritional, toxicity, efficacy and bioavailability studies

3. Toxicity profile of Tribhuvana Kirti Rasa in experimental animals.


4. Development of Opuntia elatior (fruit) based food recipes (product development) and its nutritional, toxicity, efficacy and bioavailability studies

5. Acute and Chronic (180 days) repeated dose oral toxicity study of Nimbatitkam

6. Acute and 180-days repeated dose oral toxicity study of Ayush Balrakshak Lehyam  
1. Effect of Haritkadi yoga on middle cerebral artery occlusion ischemic-reperfusion injury and its safety in rats.

2. Acute and 90 days repeated dose oral toxicity study of Coded drug AYUSH-PK Avaleha

3. Acute and 90 days repeated dose oral toxicity study of Coded drug AYUSH-SDM.

4. Development of Drug Master file and Dossier on fruit of Emblica officinalis for promising medicinal plants based on leads for Ayurveda and contemporary research. Pharmacology part.

5. Evaluation of Sveta Parpati for its curative and preventive action in Urolithiasis experimental study in rats.


6. Preclinical Evaluation (Toxicity and efficacy profile) of an Ayurvedic herbal formulation Vaisvanara Churna used in the treatment of Rheumatoid arthritis.

7. Acute and 90 days repeated dose oral toxicity study of Coded drug AYUSH-HR

8. In vitro and in vivo nephro-protective evaluation of AYUSH K1 extract.

9. In-vitro and in-vivo evaluation of anti-migraine activity of AYUSH-M3.


10. Safety and anti-obesity activity of Tryusanadi guggulu in experimental animals.

11.Acute and chronic (180 days) oral toxicity study of coded drug AYUSH RP    

The Pharmacology department is specialized in conducting Pre-clinical toxicity and biological activity evaluation studies of various Ayurvedic formulations. The department has CCSEA (M/o Fisheries Animal Husbandry and Dairying, Government of India) approved Animal House Facility (Reg.No. 591/GO/Re/S/02/CPCSEA) with the total area of 4200 sq. ft. The Department is NABL Accredited as per ISO/IEC 17025:2017 for veterinary testing of hematology samples. Also recognised as a Drug Testing Laboratory by the State Government of Tamil Nadu to carry out the drug testing for industries/academic institutes/laboratories etc and also extending services to scholars and researchers. The lab is equipped with ELISA reader for immunology and hormonal assays, activity cage for excitatory and depressant activity, swimming test apparatus for inducing stress and stress induced ulcerogenic potential studies, metabolic cages for measuring feed and water intake, urine and faecal matter collector, diuretic activity testing, Y maze, plus maze for nootropic activity, histamine chamber for anti-asthmatic activity, veterinary haematology analyser, UV spectrophotometer, Stereo zoom microscope, ECG monitoring, power lab with lab chart software, millar catheter for invasive blood pressure monitoring, CODA monitor for NIBP, Arc HPLC with Empower3 software and nitrogen evaporator for pharmacokinetic studies. In Histopathology facility, the instruments like microtome, hot air oven, incubator are present. The Animal house Facility has a barrier system under CCTV monitoring which contains clean and service corridors equipped with air shower, pass boxes, air handling units, Industrial size Autoclave, RO water facility, UV room for surface sterilization.  Isoflurane anaesthesia system is available for small animal procedures and carbon dioxide chamber for animal sacrifice. The Department have MoU with Tamil Nadu Biomedical Waste Management System for biological waste disposal. The department carries out work under Council allotted projects; CCRAS Intramural Research Projects which includes pre-clinical toxicity screening following OECD as well as CCRAS guideline along with other appropriate guidelines such as ICH, EMA etc., and efficacy studies, Collaborative projects with CSIR-IITR Lucknow, ICMR- NIN Hyderabad and many Ph. D. Projects. The department has published several papers in indexed and other reputed journals; received many awards, medals and participated in Oral and Poster presentations in National and International Conferences, Seminars/workshop and scientific meetings as invited and lead speakers. This Institute is affiliated with University of Madras, produced one PhD and currently two scholars are pursuing Ph D in the Department. The staff worked on Ayurvedic formulations such as Parpati, Churna, Vati, Lehya, Bhasma, Guggulu, Extracts, External applications, Single drugs and Eye drops.  The department has expertise on animal models like Asthma, Arthritis, Nephropathy, Migraine, Anti-inflammatory, Ocular testing, Surgical model of stroke and Obesity.

Department of Biochemistry

Department of Biochemistry was established in 1967. Currently, it is housed on the first floor of the Captain Srinivasa Murthy Central Ayurveda Research Institute, Arumbakkam, Chennai. This department has been accredited with NABL since 2008 with ISO/IEC 17025:2005 and upgraded to ISO/IEC 17025:2017 and strictly follows the NABL norms for quality assurance. This department has good instrumentation facilities. The instruments with periodic maintenance and quality control checks are done regularly to ensure the quality of test results.  The department analyses the biochemical aspects of Council allotted safety and efficacy studies and Intra Mural Research projects. This department participates in proficiency testing programs and intra-laboratory comparisons to maintain quality standards. This laboratory is an approved Drug Testing Laboratory for herbal drug analysis by the State Licensing Authority, Indian Systems of Medicine, Government of Tamil Nadu. The deparment supports the postgraduate students for their thesis research work. Several papers have been presented in conferences/seminars and several research articles have been published in well-reputed journals. Besides this, Hands-on training on sophisticated instruments and summer training is regularly provided to undergraduate and postgraduate students from various academic and research institutes. The department was equipped with sophisticated instruments like Clinical chemistry auto analyzer, RT-PCR, Gel Documentation Unit, Western Blot, UV-Visible spectrophotometer, Semi auto analyzer, Tissue homogenizer, Cooling Microcentrifuge, Deep freezer (-20°C), Electrophoresis units, pH meter, Micro centrifuges, Digital Hot top with magnetic stirrer and other accessory instruments.

Ongoing ProjectCompleted Project
प्रायोगिक चूहों में त्वचा के एपिडर्मल कार्सिनोमा के उपचार में चौलमूग्रा तेल और श्वेता सरशपा चूर्ण की कैंसर विरोधी गतिविधि। A biochemical role of AYUSH-PTK, an Ayurvedic formulation against anti-tubercular drug-induced hepatotoxicity in rats (2020-2022)Anti-atherosclerotic activity of Hirdayarnava rasa on animal model (2018-2020)Biochemical studies on Premna integrifolia Linn. in high-fat diet-induced atherosclerosis model rats (2014-2016)

Department of Microbiology

The Department of Microbiology at CSMCARI, Chennai, is an NABL-accredited testing laboratory as per ISO/IEC 17025:2017. Routine testing of AYUSH products and DTL samples are conducted in the department in accordance with API guidelines. Along with research activities involving IMR projects.  More than 100 Ayush products/samples are being tested in each financial year under IMR projects, and dissertation training/short-duration training is also being provided to the students. The department is equipped with a BSL-2 facility along with various instruments for research activities such as pH meter, Autoclave Bacteriological and BOD Incubators, colony counter, UV-Chamber, Microplate reader, cooling centrifuge, Trinocular Microscope, Cyclomixer, Magnetic stirrer, refrigerator, -40℃ deep freezer and other supporting instruments.

            Ongoing Project              Completed Project                        
1. Isolation and Identification of Endophytic Microorganisms from the stem barks used in Ayurveda (Panchavalkala) and Evaluation of their Antimicrobial, antioxidant and antibiofilm activities  
                        
2. Anti-mycobacterial screening of selected medicinal plants against common pathogenic strains of Non-Tuberculous Mycobacteria (NTM)
1. Antibacterial Activity of selective Ayurveda formulations against Gastrointestinal infection, Respiratory infection and Urinary Tract infection-causing bacteria                                                                                                         

5. Achievements & Events

About 600 research papers have been published in various national and international journals, and about 150 scientific papers have been presented in various scientific seminars, conferences and symposia. The work carried out in CSMCARI has been included in the various publications of the Department of AYUSH and ICMR, such as the following:

  1. Pharmacopeial Standards for Ayurvedic Formulations, published by Department of ISM&H, Ministry of Health & family welfare, government of India 1987.
  2. Quality Control standards for Certain Sidha Formulations, Published by Department of ISM & H, Ministry of Health & Family Welfare, Government of India, 1992.
  3. The Ayurvedic Pharmacopoeia of India, Part-II, Volume-I, published by Department of AYUSH, Ministry of Health & Family Welfare, Government of India, 2007 (Monograph on 10 Churna)
  4. The Ayurvedic Pharmacopoeia of India, Part-II, Volume-II, published by Department of AYUSH, Ministry of Health & Family Welfare, Government of India, 2008 (Monograph on 4 Churna)
  5. Quality Standards of Indian Medicinal Plants, Vol.5, published by Indian Council of Medical Research (ICMR), (Monograph on 7 Plants).
  6. Quality Standards of Indian Medicinal Plants, Vol.6, published by Indian Council of Medical Research (ICMR), (Monograph on 9 Plants).
  7. Quality Standards of Indian Medicinal Plants, Vol.7, published by Indian Council of Medical Research (ICMR), (Monograph on 11 Plants).
  8. Quality Standards of Indian Medicinal Plants, Vol.8, published by Indian Council of Medical Research (ICMR), (Monograph on 10 Plants)
  9. Quality Standards of Indian Medicinal Plants, Vol.10-17, published by Indian Council of Medical Research (ICMR), (Monograph on 80 Plants)

5.1. Approvals

1. Committee for the Control and Supervision of Experiments on Animals (CCSEA) Approval: The Institute’s Animal house facility was approved by Committee for the Control and Supervision of Experiments on Animals (CCSEA) in the year 2002.

2. Drug Testing Laboratory: The drug Controller of Tamil Nadu had accorded drug license to this institute for testing Ayurveda and Siddha Drugs in the year 2009. This facility is used by many manufacturers and researchers at large.

3. National Accreditation Board for Testing and Calibration Laboratories (NABL): The institute has been accredited with ISO/IEC: 17025 (General Requirements for the Competence of Testing and Calibration Laboratories) for Chemical (Chemistry Department) and Biological Scope (Botany/Pharmacognosy and Biochemistry) since 2008. Microbiology and Pharmacology are included under Biological scope in 2023. The scope extended to analyse all API parameters. 

4. Ph.D. research centre under the University of Madras: Academically, it is a recognized Ph.D. research centre under the University of Madras, having awarded over 40 doctoral degrees since 1979. Currently, 10 students are pursuing Ph.D under various disciplines in this institute.

5.2. Event photographs

Diamond Jubilee Celebration and International Conference on, “Integrative Approach of AYUSH Medicine in Health Care” held at National Institute of Ocean Technology campus on 6वां & 7वां January, 2023

CME programme for AYUSH Doctors/ Scientists on “Scientific Advancements in Ayush Research and Drug Standardization” held from 18वां to 23तृतीय August 2025

Medical Camp conducted at Sumaithangi Trust, Perumbakkam Chennai on September 2025

Medical Camp conducted at the Institute premises for staff and their family

4 days NABL training for CCRAS Officers and Staff conducted in June 2023

GLP training for CCRAS Officers and Staff conducted in July 2023

6. Event & Other Activity


Ayurveda Day Celebrations 2025

Hindi Fortnight Celebration 2025

International Yoga day 2025

World Environment day 2025
     
National Sports day 2025

Swachatta Hi Seva 

7. Patents and Technology Transfer

The institute claimed 08 patents for various phytochemical isolations.

क्र.सं.Patent numberPatent Filed
1.         140367A process for isolation /production of gangetin from डेस्मोडियम गैंगेटिकम D.C. (Fam: Leguminosae)
2.         140381A process for isolation /production of Tomatid-5-3-en ol from Solanum trilobatum Linn. (Fam: Solanacaae)
3.         140382A process for isolation /production of Methylangolensate and Deoxyandirobin from stem bark of Soymida febrifuga A. Juss. (Fam: Meliaceae)
4.         145857A process for isolation /production of Liriodenine-7-oxo-aporphine from the heartwood of Aquilaria agallocha Roxb.  (Fam: Thymiliaceae)
5.         150024A process for isolation /production of Vinblastine from Whole Plant (Leaves, Stem, Root) of Vinca rosea Linn. (Fam: Apocynaceae)
6.         150019A process of preparation of vincristine and vinblastine-two anticancer drugs from the whole plant (Leaves, stem, Roots) of Vinca rosea Linn. (Fam: Apocynaceae)
7.         145858A process for the isolation of 9,13-epoxy,6-hydroxy, 8-labdane 6,14,19,20-dilactone known as Nepataefolinol from the whole of Leonotis nepaetaefolia Linn. (Fam: Labiatae)
8.     147936A process for the isolation of 2—hydroxy-3-(3 methyl 1-2 butenyl)-4-napthoquinone, known as Lapachol from the root of Stereospermum tetragonum DC. (Fam: Bignoniaceae)

8. Accreditation/ Recognition of CCRAS

BIS Accreditation: The institute has been formally accredited by the Bureau of Indian Standards (BIS), specifically aligning with the IS/ISO 9001:2015, which certifies the competence and reliability of its testing and calibration laboratories. This accreditation demonstrates that the institute consistently adheres to rigorous national and international Standards in its scientific outputs. The ISO 9001:2015 certification provides a globally accepted structure for quality management systems, emphasising continual improvement, customer satisfaction, and operational excellence.

9. Annual Reports     : Annexure VI

10. Statistical Information

DepartmentOngoing ProjectsCompleted Projects
आयुर्वेद13
Botany/Pharmacognosy47
रसायन विज्ञान1028
सूक्ष्म जीव विज्ञान11
Biochemistry13
Pharmacology735
कुल2377

11. Library and publications available for sale

The institute boasts a well-equipped library housing 1,692 books, encompassing a wide range of subjects including Ayurvedic texts such as the Samhita’s, Ayurvedic and Siddha pharmacopoeias, Indian Pharmacopoeia, ICMR quality standards, comprehensive volumes on medicinal plants, and key references and journals in Ayurveda, Botany/ Pharmacognosy. chemistry, Biochemistry, Pharmacology, Microbiology, and related biomedical sciences.

11.1. Publications available for sale

CCRAS BOOKS/ PUBLICATIONS (For Sale) CSMCARI, CCRAS, CHENNAI -600 106
क्र.संName of the Books / PublicationsPubYearPriceLanguageStock
 1.Abhinav Chinthamani, Part Iसीसीआरएएस2009450हिंदी10
 2.Abhinav Chinthamani, Part IIसीसीआरएएस2009450हिंदी10
 3Application of standardised Namburi phased Spot test in Identification of Bhasma and Sindura Preparations of Ayurveda, 2nd Editionसीसीआरएएस2010130अंग्रेज़ी15
 4Aupasargikatantra targata Puyameha Vijnanamसीसीआरएएस2007190संस्कृत20
 5Ayurveda Chikitsa Mariya arogya Grihopacha – ramulu (Handbook of domestic medicine and common remedies)सीसीआरएएस2005285तेलुगू20
 6Ayurveda-Based Clinical Methods for Examination of Respiratory Diseases: Kasa & Shwasa Rogaसीसीआरएएस2021360अंग्रेज़ी5
 7Ayurveda Encyclopedia, Part Iसीसीआरएएस2013820अंग्रेज़ी23
 8Ayurveda Encyclopedia, Part IIसीसीआरएएस2013820अंग्रेज़ी24
 9Ayurveda Encyclopedia, Part IIIसीसीआरएएस2013820अंग्रेज़ी22
 10Ayurveda for Healthy Living Svasthasya Svasthya Raksanamसीसीआरएएस2018503अंग्रेज़ी6
 11Basavarajiyamसीसीआरएएस20131040अंग्रेज़ी4
 12Basic Tenets of DravyagunaNIIMH2020308अंग्रेज़ी6
 13Baswarajniyamसीसीआरएएस2007733हिंदी18
 14Brain ageing and Ayurvedaसीसीआरएएस2008360अंग्रेज़ी2
 15CakradattaNIIMH2020515अंग्रेज़ी5
 16Chakradatta- RatnaprabhaNIIMH2003240अंग्रेज़ी20
 17Chikitsarnavah (Vishwanatha Chikitsa) -Purvadhaसीसीआरएएस2010400Hindi/Sanskrit14
 18Chikitsarnavah (Vishwanatha Chikitsa) – Utthardhaसीसीआरएएस2010400Hindi/Sanskrit13
19Cikitsa Prabhakara of Shri Prabhakar Ogaleसीसीआरएएस20191000अंग्रेज़ी11
20Clinical Research Protocols for Traditional Health Scienceसीसीआरएएस20101400अंग्रेज़ी8
 21Clinical Safety Efficacy of Dhatri Lauha (A Classical Ayurvedic Formulation) In Iron Deficiency Anaemia (Pandu Roga)सीसीआरएएस2010200अंग्रेज़ी10
 22Clinical Studies of Certain Ayurvedic Formulations in the Management of Vyanabala Vaisamya (Essential Hypertension)सीसीआरएएस2009100अंग्रेज़ी9
 23Clinical Studies of Certain Ayurvedic Mutrasmaniसीसीआरएएस2008100अंग्रेज़ी1
 24Clinical Studies of Certain Ayurvedic Formulations in the Management of Paraplegia (Pangu)सीसीआरएएस2010110अंग्रेज़ी12
 25Collection and digitisation of Medical Manuscripts from South India, Maharashtra & Madhya Pradesh (CDMM): Descriptive Catalogue, Volume 1सीसीआरएएस2013780अंग्रेज़ी14
 26Collection and digitalisation of medical Manuscripts from South India, Maharashtra & Madhya Pradesh: Descriptive Catalogue, Part-2सीसीआरएएस2013780अंग्रेज़ी13
 27Compendium of Important Cereals mentioned in Ayurveda Volume 1सीसीआरएएस2021625अंग्रेज़ी5
 28Descriptive Catalogue of Medical Manuscripts Volume Iसीसीआरएएस2010450अंग्रेज़ी12
 29Descriptive Catalogue of Medical Manuscripts Volume IIसीसीआरएएस2010450अंग्रेज़ी12
 30Descriptive Catalogue of Medical Manuscripts Volume IIIसीसीआरएएस2011450अंग्रेज़ी12
 31Exploration of Veterinary Practices in Ayurveda Volume IIIसीसीआरएएस2016850अंग्रेज़ी1
 32Handbooks of Anupana Pathya & ApathyaNIIMH2012295अंग्रेज़ी2
 33Handbook of Common Siddha Kayakalpa (Rasayana) Herbs for Healthy Lifeसीसीआरएएस2008100अंग्रेज़ी1
 34Handbooks of Domestic Medicine and Common Ayurvedic Remediesसीसीआरएएस2007100उर्दू21
 35Healing Herbs of Himalayaसीसीआरएएस2008400हिंदी8
 36Healing Herbs of Himalayaसीसीआरएएस2008400अंग्रेज़ी2
 37History and Accounts- Unani MedicineNIIMH2016346अंग्रेज़ी6
 38Inventory of Animal Products used in Ayurveda, Siddha and Unani System Part Iसीसीआरएएस2008600अंग्रेज़ी2
 39Inventory of Animal Products used in Ayurveda, Siddha and Unani Systems Part IIसीसीआरएएस20081000अंग्रेज़ी2
 40Local health traditions (LHTs), oral health traditions (OHTs), and ethno-medicinal practices (EMPs): Methodical approach and critical appraisal to establish novelty and uniquenessसीसीआरएएस20212600अंग्रेज़ी6
 41Mahamahopadhyayaसीसीआरएएस2021150हिंदी4
 42Management of Chikungunya through Ayurveda and Siddhaसीसीआरएएस2009300अंग्रेज़ी21
 43Manual of Standard Operative Procedures for Prakriti Assessmentसीसीआरएएस2020250अंग्रेज़ी52
 44Marmacikitsa: Basic tenets in Ayurveda and therapeutic approachesसीसीआरएएस2020700अंग्रेज़ी21
 45Medicinal Plants in Geriatric Health Care: An Evidence-Based Approachसीसीआरएएस2008120अंग्रेज़ी10
 46Quality and Safety of select Rasakalpa (Metal & Mineral Based Ayurvedic Formulations) – Arogyavardhini Vati, Mahayogaraja Guggulu, Vasanta Kusumakar Rasa & Mahalakshmi Vilas Rasa Volume 1सीसीआरएएस2019850अंग्रेज़ी8
 47Quality and Safety of select Rasakalpa (Metal & Mineral Based Ayurvedic Formulations) – Rasmanikya, Makardhwaja, Kajjali & Rasa Sindura Volume -2सीसीआरएएस2019395अंग्रेज़ी23
 48Quality and Safety of select Rasakalpa (Metal & Mineral Based Ayurvedic Formulations) –Hridayarnava rasa Volume 3सीसीआरएएस2019350अंग्रेज़ी23
49Quality and Safety of select Rasakalpa (Metal & Mineral Based Ayurvedic Formulations) –Tamra Bhasma Volume 4सीसीआरएएस2019270अंग्रेज़ी23
 50Quality and Safety of select Rasakalpa (Metal & Mineral Based Ayurvedic Formulations) – Naga Bhasma Volume 5सीसीआरएएस2019250अंग्रेज़ी23
 51Quality and Safety of select Rasakalpa (Metal & Mineral Based Ayurvedic Formulations) – Trivanga Bhasma Volume 6सीसीआरएएस2019380अंग्रेज़ी4
 52Quality and Safety of select Rasakalpa (Metal & Mineral Based Ayurvedic Formulations) – Swarna Bhasma Volume 7सीसीआरएएस2019420अंग्रेज़ी4
 53Quality and Safety of select Rasakalpa (Metal & Mineral Based Ayurvedic Formulations) – Makaradhwaja Volume 8सीसीआरएएस2019520अंग्रेज़ी4
 54Reported Medical Practices on Prevention, Management of vector-borne and infectious diseases through Ayurveda and Siddhaसीसीआरएएस  2010540अंग्रेज़ी11
 55Report on Screening of Single Herbal Drug extracts for Potential Anti-Cancer Activityसीसीआरएएस2009100अंग्रेज़ी1
 56Research Study Profile of Rasamanikya (Classical preparation, Physico-chemical characterisation, Quality control and safety/toxicity studies of Rasamanikya)सीसीआरएएस2009230अंग्रेज़ी10
 57Safety/ Toxicity Study Report of Some Ayurvedic Drugsसीसीआरएएस2009700अंग्रेज़ी5
 58Sanskrit Medical Manuscripts in Indiaसीसीआरएएस2005300संस्कृत17
 59Select Research Papers on Rheumatoid Arthritis (Amavata)सीसीआरएएस2009100अंग्रेज़ी1
 60Salakyatantra Ayurvediya Netraroga VijnanaNIIMH2016740अंग्रेज़ी6
 61Sharabharajiyamसीसीआरएएस2007207अंग्रेज़ी18
 62Svasthya Assessment Scale (SAS)सीसीआरएएस2020470अंग्रेज़ी12
 63Textbook of Shalya Tantra Surgery in Ayurveda Volume 1सीसीआरएएस20201200अंग्रेज़ी10
 64Tribal Health Care Research (Health Related Demography of the Tribes of Andaman & Nicobar Islands)सीसीआरएएस2010300अंग्रेज़ी13
 65Tribal Health Care Research: Health Related Demography of The Tribal of Kamrup District – Assam (2002-2008)सीसीआरएएस2008300अंग्रेज़ी9
 66Vaidyak Chikitsa Sar (Pooravardha) Part – Iसीसीआरएएस2008400हिंदी9
 67Vaidyak Chikitsa Sar (Uttarardha) Part – IIसीसीआरएएस2008400हिंदी9
 68Vaidyaka prayoga vignanamu (Single Drug Therapeutics)सीसीआरएएस2007213अंग्रेज़ी11
 69Woman and Child Health Care Through Ayurvedaसीसीआरएएस2009225अंग्रेज़ी7


Suo Moto Disclosure and Activities : कैप्टन श्रीनिवास मूर्ति केंद्रीय आयुर्वेद अनुसंधान संस्थान, चेन्नई

Employee Details


Contact details:

Phone :   044-26214823 , 044-26207566                        

E-mail :  csmcari@ccras.nic.in , csmdria@gmail.com

Address :

Assistant Director In-Charge,

Captain Srinivasa Murthy Central Ayurveda Research Institute

केंद्रीय आयुर्वेदिक विज्ञान अनुसंधान परिषद (सीसीआरएएस)

आयुष मंत्रालय, भारत सरकार

A.A. Government Hospital Campus, Arumbakkam, Chennai: 600 106

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