औषधीय अनुसंधान

CCRAS is involved in Pharmacological research as part of drug development and validation of classical Ayurvedic formulations.  Toxicity and efficacy studies of Ayurvedic formulations, coded drugs and single plants are carried out as part of Pharmacology research. These studies are conducted at the Council’s peripheral Institutes Viz., Captain Srinivasa Murthy Central Ayurveda Research Institute (CSMCARI), Chennai; National Ayurveda Research Institute for Panchakarma (NARIP), Cheruthuruthy; Central Ayurveda Research Institute (CARI), Kolkata; Regional Ayurveda Research Institute (RARI), Gwalior; Regional Ayurveda Research Institute (RARI), Pune and Central Ayurveda Research Institute (CARI), Guwahati.

The experiments are conducted at experimental animal facilities of CCRAS registered under CCSEA (formerly CPCSEA) with approval of the Institutional Animal Ethics Committee (IAEC). Since inception, a total of 451 drugs have been screened for various biological (efficacy) activities, which include 267 single plants, 95 Ayurvedic formulations, and 89 coded drugs. Toxicity studies have been carried out with respect to 237 drugs comprising 74 single plants, 62 Ayurvedic formulations, and 101 coded drugs.  A total of 75 research projects (71 Intra-Mural Research Projects & 04 Collaborative Research Projects) related to toxicity and efficacy studies have been completed. Currently, 20 Intra-Mural Research Projects & 35 Collaborative Research Projects are in progress.

The collaborators of Pharmacology research include CSIR- IITR – Lucknow, CSIR- CDRI – Lucknow, CSIR- IICB – Kolkata, CSIR-IIIM- Jammu, IIT- Guwahati, NIPER- Guwahati, NIPER- Kolkata,  College of Veterinary Science (AAU), Guwahati, ACTREC- Mumbai, ICMR- NIRRCH- Mumbai, ICMR- NIN, Hyderabad, Sambalpur University, Odisha, Shiksha O Anusandhan University, Odisha, Savitri Bai Phule Pune University, ICAR-Central Institute of Freshwater Aquaculture, Bhubaneswar, Madras Veterinary College, Chennai, Bharati Vidyapeeth Deemed University, Pune, SNPS, Jadhavpur University Kolkata, IIT- BHU, JSS College of Pharmacy, Ooty, ICMR- National Institute of Research in tribal Health, Jabalpur, Indian Institute of Technology, Indore and Agarkar Research Institute, Pune.

Core Objectives – The main objectives and goals.

The primary objective is to investigate Single plants, Classical Ayurvedic formulations, and coded Ayurvedic formulations using experimental models in various animal species to establish their efficacy and safety profiles.

Peripheral Institutes Involved – A pictorial representation on the Map of India highlighting the associated peripheral institutes

Institutes Engaged in Pharmacology Research: 06 (Six)

1. कैप्टन श्रीनिवास मूर्ति केंद्रीय आयुर्वेद अनुसंधान संस्थान, चेन्नई

Year of Establishment: 1963

Experimental Animal facility: Functional CCSEA Approval No.:591/GO/Re/S/02/CPCSEA

2.  Regional Ayurveda Research Institute, Gwalior

Year of Establishment: 1970

Experimental Animal facility: Functional  CCSEA Approval No.:1020/GO/R/S/06/CPCSEA

3. National Ayurveda Research Institute for Panchakarma, Cheuthuruthy, Kerala

Year of Establishment: 1971

Experimental Animal facility: Functional CCSEA Approval No.:612/GO/R/S/02/CPCSEA

4. Central Ayurveda Research Institute, Kolkata

Year of Establishment: 1971

Experimental Animal facility: Functional CCSEA Approval No.:694/GO/RBi/S/02/CPCSEA

5. Regional Ayurveda Research Institute, Pune

Year of Establishment: 1961

Experimental Animal facility: Under Construction CCSEA Approval No.: To be allotted

6. Central Ayurveda Research Institute, Guwahati

Year of Establishment: 1971

Experimental Animal facility: Functional CCSEA Approval No.: 2332/GO/R/S/2025/CCSEA

Scientists Working: List of scientists currently working, including their designations and areas of expertise.

सहायक निदेशक (फार्माकोलॉजी)

क्र.सं.	Name & Designation (Specialization)	Area of expertise
1	Dr. Sudesh Gaidhani, Assistant Director (Pharmacology) NARIP, Cheruthuruthy Mobile: 9868849837 E-mail: sudeshgaidhani@gmail.com	Pharmacological screening of single drugs and ayurvedic formulations for safety and efficacy through animal experimentation.
2	Dr. Sanjaya Kumar. Y. R, Assistant Director (Pharmacology) CCRAS, New Delhi Mobile: 09446090579            E-mail: drsanjayayr@yahoo.com	Animal experimentation pertaining to the safety profile and efficacy of single drugs and Ayurvedic formulations.
3	Dr. S. D. Pawar, Assistant Director (Pharmacology) CARI, Kolkata Mobile: 09423508037, 020-25386715 Email id: sd_pawar@yahoo.com	Pharmacology – Proteomics, Metabolomics, Drug screening and safety studies.

Research Officer (Pharmacology)

क्र.सं.	Name & Designation (Specialization)	Area of expertise
1.	Dr. Manish M. Wanjari, Research Officer (Pharmacology) RARI, Pune Mobile: 09229205231 Email:  wmanish@yahoo.com	Metabolic disorders, inflammation, and psychopharmacology
2.	Dr. Pallavi Jamadagni,  Research Officer (Pharmacology) RARI, Pune Mobile:8668514969 E- mail: pallavideshmukh7@gmail.com	Veterinary Pharmacology and Toxicology, in-vivo and in-vitro pharmacology
3.	Dr. R. Arunadevi, Research Officer (Pharmacology) CSMCARI, Chennai Mobile: 91-9443654929 E-mail: anura24@yahoo.com	Pharmacology& Toxicology Veterinary Pharmacology, Animal Biochemistry & Animal Biotechnology
4.	Dr. Manajit Bora, Research Officer (Pharmacology) CARI-Guwahati Mobile: 9919638751 Email: manajitbora6@gmail.com	Veterinary Pharmacology & Toxicology
5.	Dr. Srikanth Ala, Research Officer (Pharmacology) NARIP, Cheruthuruthy Mobile: 4884-262366 E-mail: srikanthvbcops@gmail.com	Animal experimentations about preclinical studies like safety and efficacy of ayurvedic drugs and formulations.
6.	Dr. Lalrinpuia,  Research Officer (Pharmacology) CARI, Kolkata Mobile: 8240526532 /9862961639 E-mail: kawlni.rinpuia@gmail.com	Pharmacology & Toxicology
7.	Dr. Allakonda Lingesh, Research Officer (Pharmacology) RARI, Gwalior Mobile: 9032304269 E- mail: lingeshallakonda@gmail.com	Metabolic disorders, Neuropharmacology, Drug discovery and development
8.	Dr. Deepak Lamba,  Research Officer (Pharmacology) CCRAS, New Delhi Mobile: 9671935154 E-mail: deepaklamba786@gmail.com	Metabolic disorders, Neuropharmacology, Toxicology

Assistant Research Officer (Pharmacology)

क्र.सं.	Name & Designation (Specialization)	Area of expertise
1	Ms. N. Monika, Assistant Research Officer (Pharmacology) सीएसएमकेआरआई, चेन्नई Mobile: 7358436244 E-mail: monikanagarajan25@gmail.com	Pharmacology and Toxicology, Oncology
2	Dr. Qadir Alam, Assistant Research Officer (Pharmacology) CARI, Kolkata Mobile:9451071910 E-mail-qadir.alam786@gmail.com	Preclinical Pharmacology, computational tools in drug discovery
3	Ms.  M. Thenmozhi, Assistant Research Officer (Pharmacology) CSMCARI, Chennai Mobile: 9750671768 E–mail-thenprabhu2014@gmail.com	Ocular Pharmacology/animal models for Arthritis
4	Dr. Nalban Nasiruddin, Assistant Research Officer (Pharmacology) आरएआरआई, पुणे Mobile: 8330903452	In-vivo Drug screening and safety studies.
5.	Dr.  M.  Kalyan Kumar Raju, Assistant Research Officer (Pharmacology) CARI, Kolkata Mobile: 8240862753/ 8402921807 E–mail- mkalyankumarraju@gmail.com	Pharmacological screening, Toxicity testing of Ayurvedic coded drugs/ Formulations, In vitro cell culture and Histopathology.
6.	Dr. Sudhir  D. Matte, Assistant Research Officer (Pharmacology) RARI, Pune Mobile: 9359547279 E-mail-sudhir.m@ccras.nic.in sudhirmatte1991@gmail.com	In-vivo Pharmacological studies and clinical pharmacology
7.	Dr. K. C. Harita Yadav, Assistant Research Officer (Pharmacology) CSMCARI, Chennai Mobile: 9985732306 E-mail-kcharitha9@gmail.com	Cardiovascular and metabolic activities, Anti-obesity activity, Hypolipidemic activity, and Gastrointestinal disorders
8.	Mr. Tamboli Munaf Ayub, Assistant Research Officer (Pharmacology) RARI, Pune Mobile :7709053157 E-mail-munaf2050@gmail.com	In-vivo Drug screening and safety studies.

Research Officer (Animal Experimental Pathology)

क्र.सं.	Name & Designation (Specialization)	Area of expertise
1.	Dr. Shrirang B. Jamadagni, Research Officer (Animal experimental pathology) RARI-Pune Mobile: 9477266765 E-mail: nribas-pune@gov.in; nribas.pune@gmail.com	Veterinary Pathology, Animal / Experimental Pathology, Toxicologic Pathology
2.	Dr. Jeevan K, Research Officer (Animal Experimental Pathology) RARI, Gwalior Mobile 8660580015 E-mail: jeevank1116@gmail.com jeevan.k@ccras.nic.in	Pathological evaluations related to rodent model of hepatocarcinogenesis, metabolic disorders, Degenerative studies, and various toxicity studies
3.	Dr. Rahul Singh, Research Officer (Animal Experimental Pathology) CARI, Kolkata Mobile: 8755875983 E-mail: drahul.sigh1987@gmail.com	Clinical Pathology, Cytopathology, Immunohistochemical Staining, Anatomic Pathology and Histopathology.

Infrastructure and Facility-Based Information

Experimental Animal House: National Ayurveda Research Institute for Panchakarma (NARIP), Cheruthuruthy

Experimental Animal House: Central Ayurveda Research Institute (CARI), Kolkata

Experimental Animal House: Regional Ayurveda Research Institute (RARI), Gwalior

Experimental Animal House: Regional Ayurveda Research Institute (RARI), Pune

Experimental Animal House: Captain Srinivasa Murthy Central Ayurveda Research Institute (CSMCARI), Chennai

Experimental Animal House: Central Ayurveda Research Institute (CARI), Guwahati.

Sophisticated instruments:

GLP Status/Accreditation/Certification/Recognition

Currently, CCRAS has four functional animal houses, each with its respective CCSEA approval. These include the Captain Srinivasa Murthy Central Ayurveda Research Institute in Chennai (CCSEA Approval No.: 591/GO/Re/S/02/CPCSEA), the Regional Ayurveda Research Institute in Gwalior (CCSEA Approval No.: 1020/GO/R/S/06/CPCSEA), the National Ayurveda Research Institute for Panchakarma in Cheuthuruthy, Kerala (CCSEA Approval No.: 612/GO/R/S/02/CPCSEA), and the Central Ayurveda Research Institute in Kolkata (CCSEA Approval No.: 694/GO/RBi/S/02/CPCSEA). Central Ayurveda Research Institute in Guwahati, experimental animal facility (CCSEA Approval No.: 2332/GO/R/S/2025/CCSEA)) Meanwhile, the experimental animal facility at the Regional Ayurveda Research Institute in Pune is under construction.

Two CCRAS institutes, Captain Srinivasa Murthy Central Ayurveda Research Institute in Chennai and the Regional Ayurveda Research Institute in Gwalior, are currently in the process of obtaining GLP accreditation.

Research Projects:

Completed IMR Projects:

Project Code	Title of the project	Status
IPG0001	Preclinical evaluation of compound Ayurvedic formulation (Ayush MANAS)	पुरा होना।
IPG0002	Preclinical (Acute & Chronic) studies of Yograj Guggulu	पुरा होना।
IPG0003	Preclinical (Toxicity) Study of compound Ayurvedic Formulations, Ayush SL	पुरा होना।
IPG0004	Preclinical (Acute, Subacute & Chronic Toxicity) Study of compound Ayurvedic formulation Ayush M	पुरा होना।
IPG0005	Preclinical (Acute, Subacute and Chronic Toxicity) study of Compound Ayurvedic Formulation Ayush QOL-2	पुरा होना।
IPG0006	Preclinical studies (Acute & Chronic toxicity) of Mahanarayana Taila	पुरा होना।
IPG0007	28 Days Sub-acute Toxicity and 91 Days chronic Toxicity (oral)study of Wj in Wistar Albino Rats and Swiss albino mice	पुरा होना।
IPG0008	28 Days sub-acute toxicity and 90 Days chronic Toxicity (oral) studies of Ayurvedic Bhasma/ Rasakalpa  Yn in Wistar Albino Rats and Swiss  albino mice.	पुरा होना।
IPG0009	28 days Sub Acute Toxicity studies and 91 days Chronic toxicity (oral) studies of Ayurvedic Bhasma/ Rasakalpa ZJ in wistar albino rats and swiss albino Mice.	पुरा होना।
IPG0010	To evaluate and explore the mechanism of action of anti-cancer Ayurvedic plants using cell-based assays	पुरा होना।
IPG0011	Exploratory Evaluation of Jatyadi Ghrita for wound healing properties on chronic excision wound in diabetes-induced rats	पुरा होना।
IPG0012	Evaluation of Hypoglycemic, Hepatoprotective, and Anti-Dyslipidemic Activity of Parijata (Nyctanthes arbor–tristis linn.) Flower extract in experimental animals	पुरा होना।
IPG0013	Evaluation of Antidiabetic Activity of Ficus Gibbosa Blume (leaves and stem bark) Extracts in Streptozotocin nicotinamide induced Diabetes in experimental animals	पुरा होना।
IPG0014	Evaluation of hypolipidemic activity of Cardiospermum hallicacabum Linn.	पुरा होना।
IPG0015	Pharmacological Evaluation of Gokshuradi Guggulu in Experimentally – induced Urolithiasis in Rats	पुरा होना।
IPG0016	Toxicological and Antiarthritic Evaluation of Laghu Vishgarbha Taila	पुरा होना।
IPG0017	In vitro assessment of anti-diabetic                                    Ayurvedic formulation using cell-based assays	पुरा होना।
IPG0018	Biochemical evaluation of the Anti-Atherosclerotic Activity of Premna integrifolia Linn. (Agnimantha) in experimental Animal model	पुरा होना।
IPG0019	Evaluation of Sweta Parpati for its curative and Preventive action in Urolithiasis experimental study in rats	पुरा होना।
IPG0020	Preclinical Evaluation (Toxicity and Efficacy Profile) of An Ayurvedic Herbal Formulation Vaisvanara Churna used in the treatment of Rheumatoid Arthritis	पुरा होना।
IPG0021	Exploratory evaluation of Hepatoprotective activity of Aarogyavardhini vati in experimental animal models	पुरा होना।
IPG0022	Antidiabetic activity of Mimosa pudica	पुरा होना।
IPG0023	Development of Coded drug AYUSH – M3 for the management of Migraine patients.	पुरा होना।
IPG0024	Development of Coded drug AYUSH PJ 7 for the management of dengue patients.	पुरा होना।
IPG0025	To evaluate the safety/ toxicity studies of cannabis Leaves	पुरा होना।
IPG0026	Anti-inflammatory activity of ShunthiGuggulu	पुरा होना।
IPG0027	Analgesic activity of SG 1, SG 2, SG 3, SG 4 and SG 5.	पुरा होना।
IPG0028	Effect of Haritkadi Yoga on middle cerebral artery occlusion ischemic-reperfusion injury and its safety in rats	पुरा होना।
IPG0029	Biochemical and Pharmacological Evaluation of Kaishore Guggulu in Experimental Models of Gout (Vatarakta)	पुरा होना।
IPG0030	In-vitro evaluation of anti-diabetic activity of AYUSH-82 using proteomic and metabolomic tools	पुरा होना।
IPG0031	In-vivo anti-diabetic activity of AYUSH-82	पुरा होना।
IPG0032	Preclinical safety/toxicity and hepatoprotective activity of Ayush Phalatrikadi Kwath	पुरा होना।
IPG0033	Ocular toxicity of coded Ayurvedic eye drop PE drops for conjunctivitis	पुरा होना।
IPG0034	Toxicity profile of Gomutra Haritaki (GMH)	पुरा होना।
IPG0035	Development of Medicinal Plant Garden for Veterinary Ayurveda Research	पुरा होना।
IPG0036	प्रायोगिक पशुओं में विभिन्न गठिया मॉडल के माध्यम से गठिया विरोधी गतिविधि के लिए वटारि गुग्गुलु का मूल्यांकन	पुरा होना।
IPG0037	Evaluation of Anti-arthritic activity of Trayodashang guggulu in Complete Freund’s Adjuvant-induced Arthritic Rat Model	पुरा होना।
IPG0039	In-vivo and in-vitro nephroprotective evaluation of AYUSH K1 extract	पुरा होना।
IPG0040	Pharmacological study of AYUSH-SHY in Zebrafish.	पुरा होना।
IPG0041	Anti-atherosclerotic activity of Hridayarnava Rasa against atherosclerosis in animal model	पुरा होना।
IPG0042	Evaluation of in-vitro safety study of some Ayurvedic drugs/plant extracts with special reference to Genotoxicity	पुरा होना।
IPG0043	Evaluation of Kanchanar Guggulu against chemically induced hypothyroidism in rats	पुरा होना।
IPG0044	Study of Carica papaya Leaf, Adhatoda vasaca Leaf and Tinospora cordifolia Stem in Experimental Thrombocytopenia as model of Dengue	पुरा होना।
IPG0045	Clinical evaluation of efficacy of Ayurvedic formulation (Ayush V-13) for augmentation of Milk production in ruminants	पुरा होना।
IPG0046	जुगाली करने वालों में चयनित गैस्ट्रो आंत्र रोग के प्रबंधन में आयुष वी-24 (एक कोडित आयुर्वेदिक फॉर्मूलेशन) की प्रभावकारिता का नैदानिक मूल्यांकन	पुरा होना।
IPG0047	Pharmacological Evaluation of Kutajghan Vati in Experimentally-induced Colitis in Rats	पुरा होना।
IPG0048	Exploration of safety and reproductive toxicity profile of AYUSH-AG tablets.	पुरा होना।
IPG0049	Exploration of safety and reproductive toxicity profile of AYUSH-GG tablets.	पुरा होना।
IPG0050	Evaluation of acute toxicity of some Ayurvedic Drugs/Plants extracts in-vivo model of Zebrafish.	पुरा होना।
IPG0051	Exploration of Medhya properties (neuroprotective effect) of Yastimadhu (Glycyrrhiza glabra Linn.), Guduchi (Tinospora cardifolia) and Vacha (Acorus calamus) in animal model of neurotoxicity.	पुरा होना।
IPG0052	Evaluation of Anti-inflammatory, anti-arthritic and analgesic activity of Simhanada guggulu on experimental animal models.	पुरा होना।
IPG0053	Effect of Nishatriphala Yoga on Streptozotocin and High fat diet induced diabetic neuropathy in Sprague Dawley rats.	पुरा होना।
IPG0054	In-vitro and in-vivo evaluation of anti-migraine activity of AYUSH- M3.	पुरा होना।
IPG0055	Exploratory study of cellular and nuclear entry of Bhasmas/rasakalpas.	पुरा होना।
IPG0056	Evaluation of anti-diabetic activity of Vasant Kusumakar Ras in Streptozotocin and high fat diet-induced diabetes in experimental animals.	पुरा होना।
IPG0057	Study on biochemical markers for neuroprotective role of Sarasvata Ghrita in aluminum chloride-induced rat model of Alzheimer’s disease.	पुरा होना।
IPG0058	Toxicity study and evaluation of Anti-dyslipidemic activity of Vyosadi Guggulu in wistar rats.	पुरा होना।
IPG0059	A biochemical role of AYUSH-PTK, an Ayurvedic Formulation against Anti-tubercular drug-induced hepatotoxicity in rats.	पुरा होना।
IPG0060	Acute and 90-day oral toxicity study of AYUSH-SS granules in experimental animals.	पुरा होना।
IPG0061	Acute and 90-days oral toxicity study of AYUSH-LND in experimental animals	पुरा होना।
IPG0062	Evaluation of Kalyanaka Ghrita against rat model of Alzheimer’s disease.	पुरा होना।
IPG0063	Acute oral toxicity and 90 days repeated dose oral toxicity study of coded drug AYUSH PK Avaleha.	पुरा होना।
IPG0064	Acute and 90 days repeated dose oral toxicity study of coded drug AYUSH-SDM tablet.	पुरा होना।
IPG0065	Acute and 90 days repeated dose oral toxicity study of coded drug Ayush-HR	पुरा होना।
IPG0068	Antiarthritic activity of Ayush SG-5 in Experimental Animals	पुरा होना।
IPG0069	Acute and 90 days repeated dose oral Toxicity Study of Ayush-SC 3 in Experimental Animals	पुरा होना।
IPG0072	Exploration of reproductive toxicity profile of AYUSH SS granules.	पुरा होना।
IPG0073	Evaluation of anti-depressant/anxiolytic/ nootropic effect of Panchagavya Ghrita in experimentally induced stress in rats.	पुरा होना।
IPG0074	कोडित दवा आयुष 64 की प्रजनन विषाक्तता प्रोफ़ाइल की खोज	पुरा होना।
IPG0076	Effect of Brahmidrakshyadi kashaya on chronic restraint stress (CRS) induced neurobehavioral alterations in experimental Rats	पुरा होना।
IPG0077	Comparative evaluation of selected Ayurvedic Pharmacopoeial source plants and their substitutes through Experimental Pharmacology	पुरा होना।

Completed Collaborative Projects:

Project code	Project	Participating Institute	Collaborating Institute	Status
CPG0001	Pre-clinical evaluation of Ayurvedic formulations against ionizing radiation-induced acute dermal injury in rats-implications in clinical study.	आरएआरआई, ग्वालियर	INMAS New Delhi	पुरा होना।
CPG0002	Evaluation of hepatoprotective efficacy and underlying molecular mechanism of Ayurvedic formulations, AYUSH-PKT & AYUSH-GMH in experimental animal models of alcoholic and non-alcoholic fatty liver diseases: A pre-clinical study	आरएआरआई, ग्वालियर	ILBS, New Delhi	पुरा होना।
CPG0007	Evaluation of Cytotoxicity, Pharmacokinetics, Anti-Cancer Activity, Detailed Molecular Mechanisms of Bhallatakadi Modaka in In Vitro (2D and 3D Culture) and in vivo Tumor Xenograft Models	CARI (Kolkata)	CSIR-IICB (Kolkata)	पुरा होना।
CPG0008	Toxicity Studies and Evaluation of Anti-inflammatory and Anti-arthritic activity of Shunthi Guggulu (Triphala Shodhita) in Rats	सीएआरआई, गुवाहाटी	CVSc, Guwahati	पुरा होना।

Ongoing IMR Projects:

Project Code	Title of the project	Status
IPG0038	प्रायोगिक मधुमेह अपवृक्कता पर गोक्षुरादि गुग्गुलु का प्रभाव: इन-विट्रो और इन-विवो अध्ययन	Ongoing
IPG0066	Clinical evaluation of the efficacy of Padmakanta Yoga, an Ayurveda Formulation in the management of Mastitis in Bovines.	Ongoing
IPG0067	Acute and 90 days repeated dose oral toxicity study of Ayush-64 in Experimental Animals	Ongoing
IPG0070	Evaluation of Anti-diabetic and Hepatoprotective Activity of Coded Formulation AYUSH-64 in Experimental Animal Models.	Ongoing
IPG0071	Evaluation of Kanchnar Guggulu and Varunadi Kashaya against letrozole-induced polycystic ovarian syndrome associate conditions in female Wistar rats.	Ongoing
IPG0075	Evaluation of some medicinal plants against free fatty acid induced steatosis in hepatic cell line- In vitro study.	Ongoing
IPG0078	Safety and anti-obesity activity of Tryusanadi Guggulu in experimental animals	Ongoing
IPG0079	Study of coded drugs intended for antenatal care i.e., AYUSH-GG and AYUSH-AG for their developmental toxicity and teratogenicity profiles in zebrafish embryo model	Ongoing
IPG0080	Anti-cancer activity of Chaulmoogra oil and Shwetha Sarshapa churna in the treatment of epidermal carcinoma of skin in experimental mice	Ongoing
IPG0081	Acute and chronic oral toxicity study of coded drug AYUSH RP (180 days)	Ongoing
IPG0082	Acute and Sub Chronic (90 days) repeated dose oral toxicity study of AYUSH GMH in Experimental animals	Ongoing
IPG0083	Evaluation of selected Ayurvedic plants and formulations for their anti-diabetic activity using in-silico screening and its in-vitro validation	Ongoing
IPG0086	Acute and 90 days oral toxicity study of AYUSH-Bal Ghutti in experimental animals	Ongoing
IPG0087	Study of selected Ayurvedic herbs for their anti-angiogenic potential and toxicity profile in zebrafish embryo model for cancer management	Ongoing
IPG0088	Anti-hyperuricemic and anti-gouty arthritis activities of Amritadi Guggulu on monosodium urate crystal-induced in Wistar rats	Ongoing
IPG0089	Evaluation of acute dermal toxicity, 90 days repeated dose dermal toxicity, analgesic and anti-inflammatory activities of AYUSH MML Oil in Wistar rats	Ongoing
IPG0091	Biochemical Effect of Trikatu Churna in Methimazole induced Experimental Hypothyroidism in Wistar Rats	Ongoing
IPG0092	Acute and chronic (180 days repeated dose) oral toxicity of coded drug–AYUSH-Bal Rasayana in experimental animals.	Ongoing
IPG0093	Evaluation of Acute, Sub-acute (28- days) and Chronic (180 days) repeated dose oral toxicity study of AYUSH-56 on experimental animal models	Ongoing
IPG0094	Acute and 180-days repeated dose oral toxicity study of AYUSH Bal rakshak Lehyam.	Ongoing
IPG0095	Acute and Chronic (180) days repeated dose oral toxicity study of Nimbatiktam in rats as per the OECD guidelines (423 and 452)	Ongoing
IPG0096	Evaluation of acute and 90 days sub chronic dermal toxicity of Ayush LK Gel	Ongoing

Ongoing Collaborative Projects:

Project code	Project	Participating Institute	Collaboration Institute	Status
CPG0003	Evaluation of drugs-cytochrome P450 enzyme interaction through fluorometric high throughput screening assays.	आरएआरआई, पुणे	NIRRH Mumbai	Ongoing
CPG0004	डिम्बग्रंथि के कैंसर के खिलाफ इम्यूनोमॉड्यूलेटरी और एंटीकैंसर फॉर्मूलेशन के रूप में कैरक्टोल-एस की यंत्रवत भूमिका को समझना	सीएआरआई, मुंबई	ACTREC, Mumbai.	Ongoing
CPG0005	ल्यूकेमिया, लिम्फोमा, मेलानोमा, फेफड़े और स्तन कैंसर के पूर्व-नैदानिक मॉडल के खिलाफ इम्यूनोमॉड्यूलेटरी और कैंसर-रोधी यौगिकों के रूप में CARAF और CAGHE की यंत्रवत भूमिका को समझना	सीएआरआई, मुंबई	ACTREC, Mumbai.	Ongoing
CPG0006	Mechanistic investigations on the efficacy and mode of action of Ashwagandha और Yogaraj Guggulu, using a hybrid Proteomics-Cheminformatics-Network medicine approach for the treatment of Osteoarthritis	CARI (Kolkata)	IIT (Guwahati)	Ongoing
CPG0009	Deciphering pharmacodynamics of Ayurvedic formulations (AYUSH Manas, Amrit Bhallataka Ghrita and Jyotishmati Taila) used in the Treatment of Neurodegenerative Diseases by Integrating Reverse Pharmacological Approaches.	सीएआरआई, कोलकाता	NIPER, Guwahati	Ongoing

Project code	Project	Participating Institute	Collaboration Institute	Status
CPG0010	डिम्बग्रंथि के कैंसर कोशिकाओं पर रस सिंधुर की कैंसर विरोधी क्षमता और आणविक तंत्र	सीएआरआई, कोलकाता	CSIR-IICB, Kolkata	Ongoing
CPG0011	का विकास Opuntia elatoir (fruit) based food recipes (product development) and its nutritional, toxicity, efficacy and bioavailability studies.	एनआईआईएमएच, हैदराबाद	ICMR-NIN, Hyderabad	Ongoing
CPG0012	Toxicity profiling of Mrityunjaya rasa in experimental animals.	आरएआरआई, ग्वालियर	IITR, Lucknow	Ongoing
CPG0013	Toxicity profile of Tribhuvana kirti Rasa in experimental animals.	सीएसएमकेआरआई, चेन्नई	IITR, Lucknow	Ongoing
CPG0014	Toxicity profile of Rasamanikya Rasa in experimental animals.	सीएआरआई, कोलकाता	IITR, Lucknow	Ongoing
CPG0015	Aqueous and hydroalcoholic    extraction of selected Anukta Dravya plants and evaluation   of their therapeutic efficacy for      various diseases.	सीएआरआई, कोलकाता	Sambalpur University (SU), Odisha	Ongoing
CPG0016	Preclinical study on efficacy, safety and toxicity of Swarna Prashan Regimen as Adjunct therapy in Pediatric Acute Lymphoblastic Leukemia.	सीएआरआई, मुंबई	NIRRH, Mumbai	Ongoing
CPG0017	Toxicity profile of Swaskuthar Rasa in experimental animals.	एनएआरआईपी, चेरुथुरुथी	IITR, Lucknow	Ongoing
CPG0018	Evaluation of anti-cancerous potential, in-silico pharmacological analysis and molecular mechanism of Kanchanar guggulu in ovarian cancer µTumor spheroids, and in विवो में models.	सीएआरआई, कोलकाता	CSIR-IICB, Kolkata	Ongoing
CPG0019	का विकास Madhuca longifolia (Flower) based food recipe (Product development) and its nutritional, toxicity, efficacy and bioavailability studies.	एनआईआईएमएच, हैदराबाद	ICMR-NIN, Hyderabad	Ongoing
CPG0020	Pre-Clinical Study of Dhatri Lauha (A classical ayurvedic formulation) in Iron Deficiency Anaemia (Pandu Roga).	सीएआरआई, झाँसी	CSIR-CDRI- Lucknow	Ongoing
CPG0021	Pre-clinical development of Guduchi (Tinospora cordifolia (Thunb) Miers) stem through AYUSH route for adjunct therapy in tuberculosis to reduce anti-tubercular treatment (ATT) induced hepatotoxicity.	सीएआरआई, झाँसी	CSIR-CDRI- Lucknow & CSIR-IIIM- Jammu	Ongoing
CPG0022	Pre-clinical development of Amalaki (Phyllanthus emblica Linn.)  fruit through AYUSH route as adjunct therapy in tuberculosis to reduce anti-tubercular treatment (ATT) induced hepatotoxicity.	सीएआरआई, झाँसी	CSIR-CDRI- Lucknow & CSIR-IIIM- Jammu	Ongoing
CPG0023	Pre-clinical development of Vasa (Justicia adhatoda Linn.) leaves through AYUSH route as adjunct therapy in tuberculosis to reduce anti-tubercular treatment (ATT) induced hepatotoxicity.	सीएआरआई, झाँसी	CSIR-CDRI- Lucknow & CSIR-IIIM- Jammu	Ongoing
CPG0024	Mechanistic studies with Withania Somunifera extracts and its major phyto-constituents on innate immune cell responses and their efficacy in experimentl animl models of immune-supression and inflammation	CARI, Lucknow	CDRI, Lucknow	Ongoing
CPG0025	Evaluation of the inhibition potential of ayurvedic drugs against cytochrome p450: Implications for drugs-drug Interaction.	सीएआरआई, कोलकाता	NIPER Kolkata	Ongoing
CPG0026	Evaluation of Neuroprotective potential of Brahmi Ghrita, Panchgavya Ghrita and Ayush 56 in epilepsy model, its functional significance and mechanism.	सीएआरआई, कोलकाता	CSIR – IICB, Kolkata	Ongoing
CPG0027	Evaluation of effect of AYUSH M3 and Prabhakar vati on cardiovascular parameters.	सीएआरआई, कोलकाता	CSIR-CDRI, Lucknow	Ongoing
CPG0028	Elucidating mechanisms of anti-hyperglycemic activity of selected herbal formulations	CARI Bangalore	Bharati Vidyapeeth Deemed to be University, Pune	Ongoing
CPG0029	Evaluation of Brahmi Ghrita in in-vitro and in-vivo models of Alzheimer’s disease	एनएआरआईपी, चेरुथुरुथी	JSS College of Pharmacy, Ooty,	Ongoing
CPG0030	Preclinical Evaluation and the Molecular Mechanism of Ayush-64 against Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) in murine model	सीएआरआई, कोलकाता	NIPER, Kolkata	Ongoing
CPG0031	Aqueous and ethanolic extraction of two promising extra-pharmacopoeial (AnuktaDravya) plants and evaluation of their anti-inflammatory and wound-healing activities.	CARI-Bhubaneswar	Siksha O Anusandhan Bhubaneswar	Ongoing
CPG0032	Acute and Ninety days repeated dose (Sub-chronic) oral toxicity study of coded formulation Ayush-PTK.	सीएआरआई, गुवाहाटी	College of Veterinary Science, Guwahati	Ongoing
CPG0033	Assessment of Anti-aging, Antimutagenic and Cancer Chemoprevention potential of Swarna Bhasma in Drosophila melanogaster	RARI Pune & RRAP-CARI, Mumbai	SPPU, Pune	Ongoing
CPG0034	Cardioprotective effect of Pushkara Guggulu on experimentally induced myocardial infarction in rats.	कैप्टन श्रीनिवास मूर्ति केंद्रीय आयुर्वेद अनुसंधान संस्थान, चेन्नई	Madras Veterinary College, Chennai	Ongoing
CPG0036	Chemopreventive Effects of Opuntia elatior Fruits Against Chemotherapy-Induced Toxicity in Ovarian Cancer Pre-Clinical Models	केंद्रीय आयुर्वेद अनुसंधान संस्थान, कोलकाता	CSIR – IICB, Kolkata	Ongoing
CPG0037	Evaluation of Coded drug Ayush Rasayana B for treatment of high-altitude sickness using multi-dimensional drug discovery approach	सीएआरआई, कोलकाता	IIT BHU, Varanasi	Ongoing
CPG0038	Evaluation of Neuroprotective and Antioxidant Effects of Vasantakusumakara rasa in a rat Model of Type II diabetes neuropathy	CARI-Guwahati	C.V.Sc., Guwahati	Ongoing
CPG0039	Standardization of Sustainable Medicinal Leech Farming Technology and Evaluating its Clinical Efficacy and Safety.	CARI-Bhubaneswar	ICAR-Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar	Ongoing
CPG0040	Evaluation of Vidangadi Lauham, a classical Ayurvedic formulation in the management of diabetes in experimental animals.	CARI Kolkata CARI Jhansi	SNPS, Jadavpur University, Kolkata	Ongoing
CPG0041	Targetting antibiotic resistant gut pathogen-induced acidpeptic Disease through ayurvedic formulations.	CARI Kolkata CARI Jhansi	IIT Indore	Ongoing

Publications:

क्र.सं. नहीं।	Title of research Paper	Authors	Name of the Journal, Vol. No. Year, Page No.
1	Evidence-based study of Hridayarnava Rasa: An Ayurvedic formulation in experimentally induced atherosclerotic cardiovascular disease.	Chitra S, Jamadagni S, Gaidhani SN, Ilavarasan R, Narasimha VE	Journal of Drug Research in Ayurvedic Sciences, 2024; 9(3): 138-149.| DOI: 10.4103/jdras.jdras_68_23
2	Evaluation of Anti-arthritic and in-vitro Anti-inflammatory activity of Vaisvanara Churna.	Ilavarasan R, Arunadevi R, Kusuma G, Gaidhani SN, Thenmozhi M, Manikandan N.	J Ethnopharmacol. 2025 Jan 30;337(Pt 1):118774. doi:10.1016/j.jep.2024.118774. Epub 2024 Aug 31.
3	Quality control analysis, phytochemistry, and pharmacognosy of  botanical source plants for Murva [Chonemorpha fragrans (Moon) Alston and Marsdenia tenicissima (Roxb.)Moon]: A comparative assessment.	Gaidhani SN, Thirupataiah B, Thulasi R, Nair PG, Misro L, Reddy V, Ala S, Kumar SYR	IJNPR, 16(1), 2025, 135-159.
4	Safety of Ayush OSTO in experimental animals	Gaidhani SN, Padhi MM, Singh A, Reddy V, Ala S	International Journal of Ayurveda Research, 5(2), 2024: 108-14.
5	Preclinical safety assessment of Ayush Carctol -S through acute and sub chronic oral toxicity study: Safety assessment of Ayush Carctol S.	Gaidhani SN, Reddy D, Ganesan R, Pawar T, Srikanth N, Padhi MM, Reddy V, Ala S.	Toxicology International. 31 (4), 2024: 539-549.
6	Commelina benghalensis attenuates cyclophosphamide-induced hepatotoxicity by preserving hepatic mitochondrial activity through upregulating pro-mitochondrial proteins	Allakonda L, Potnuri AG, Kumar Dokuparthi S, Danaboina GB, Subramanyam K.	Traditional and Kampo Medicine, 11. 2024, 230-241
7	Predicting the skin sensitizing potential of pesticides using Pred-Skin 3.0- A web based prediction tool	Potnuri AG, Allakonda L, Ajith K	Toxicology in Vitro, 104. 2025. 104, 106015
8	Anti-arthritic activity of Trayodashang guggulu, a classical Ayurvedic formulation against complete Freund’s adjuvant-induced rheumatoid arthritis in rats.	Bora M, Sinha BM, Dixit AK, Jamadagni S, Gaidhani SN, Gautam MK, Upadhyaya S, Hazra J, Srikanth N.	Journal of Basic and Applied Zoology 85, 44 (2024). DOI: https://doi.org/10.1186/s41936-024-00398-2.
9	Preclinical Pharmacology of Some Important Indian Medicinal Herbs in Animal Models and Their Mode of Action,	Bora M, Gautam MK, Chowdhury SR, Pawar SD, Chakraborty R, Dash B, Deb NK, Mondal S, Teli A.	Natural Medicine Vol. 3, 2024; 212-227. Bentham Publishers. DOI: https://doi.org/10.2174/9789815238129124030009
10	Safety Evaluation of Vyosadi Guggulu, an Ayurvedic Formulation through Acute and Subchronic Toxicity Studies in Wistar Rats.	Bora M, Lalrinpuia K, Dixit AK, Alam Q, Pawar SD, Sanjaya Kumar YR, Gaidhani SN, Sinha BM, Jamadagni SB, Babu G.	Toxicology International, 32(1): 81-89; 2025. DOI: 10.18311/ti/2025/v32i1/43653
11	A review on Pharmacological activities of Pseudarthria viscida (L) Wight & Arn.	Sanjaya Kumar YR, Lamba D, Chauhan VK, Srikanth N.	World Journal of Pharmacy and Pharmaceutical Sciences. 2024, 13 (5): 177-184.
12	Potential of Coriandrum sativum in management of Diabetes and Hyperlipidemia: A Comprehensive Review of Pharmacological Evidence and Mechanisms	Sanjaya Kumar YR, Lamba D, Chauhan VS, Srikanth N, Khanduri S.	International Journal of Basic & Clinical Pharmacology. 2025, 14 (2): 324-329.
13	Antidiabetic Activity of Ficus gibbosa Blume Extracts in Streptozotocin–Nicotinamide-induced Diabetes in Sprague Dawley Rats.	Sanjaya Kumar YR, Lakshmi OS, Selvam N Thamizh, Vasanthakumar KG, Deep VC, Ala Srikanth, Gaidhani Sudesh N, Swamy G Kumara.	Journal of Drug Research in Ayurvedic Sciences 5(1): 57-62, Jan–Mar 2020. (DOI: 10.5005/jdras-10059-0094).
14	Oral toxicity evaluation of Gokshuradi guggulu, an ayurvedic formulation.	Wanjari MM, Dey YN, Yadav M, Sharma D, Srivastava B, Jamdagni SB, Gaidhani SN, Pawar S.	Drug and Chemical Toxicology, 2021, 45(5): 1986-1994. https://doi.org/10.1080/01480545.2021.1894725.
15	Acute and Sub-chronic Oral Toxicity Study of Classical Ayurvedic Formulation Yogaraja Guggulu.	Sanjaya Kumar YR, Thamizh Selvam N, Gaidhani SN, Lamba D, Sharma BS, Chauhan VS, Srikanth N.	Research Journal of Pharmacy and Technology. 2025;18(5):2175-0. doi: 10.52711/0974-360X.2025.00312
16	Isolation, Structural Characterization and Evaluation of In-vitro Anti-tubercular Activity of Quercetin from Leaves of Tragia involucrata	Thenmozhi M, Gokul M, Vikram ENT, Muthukrishnan K.	Toxicology International .Online ISSN: 0976-5131 Print ISSN : 0971-6580
17	Antioxidant, antibacterial and antibiofilm activities of Pittosporum napaulense (DC.) against drug-resistant Staphylococcus aureus and Shigella sp	Sajna Sameekshya Hota, Dibya Ranjan Sahoo, Subhaswaraj Pattnaik, Monika Mishra, Tapasa Mishra, Tanuja Sahu, Baishali Basundhara Naik, Malayamarutham Kalyankumarraju, Amit Kumar Dixit, Deepak Lamba, Sanjaya Kumar Y. R., Rabinarayan Acharya & Pradeep Kumar Naik	Natural Product Research, Pages: 1-9;  2024/1
18	Evaluation of fertility toxicity and embryo-fetal developmental toxicity profile of Ayush AG, a compound herbo-mineral Ayurvedic formulation.	Jamadagni SB, Tambe M, Srinivasan M, Gaidhani S, Prasad GP, Matte S. Jun 28;16(4):101154. doi: 10.1016/j.jaim.2025.101154.	J Ayurveda Integr Med. 2025 Epub ahead of print. PMID: 40582044; PMCID: PMC12266510.
19	Antidyslipidemic activity of hydro-alcoholic extract of Parijata (Nyctanthes arbor-tristis L.) flower in Wistar albino rats.	Bora M, Jamadagni SB, Upadhyay SN, Mitra A, Mondal, DN, Mukherjee K, Gaidhani SN, Kumar YR Sanjaya.	Int J Ayurveda Res 6(2): 145-151, Apr–Jun 2025. DOI: 10.4103/ijar.ijar_84_24

Major Achievements:

Since inception, a total of 451 drugs have been screened for various biological (efficacy) activities, which include 267 single plants, 95 Ayurvedic formulations, and 89 coded drugs. Toxicity studies have been carried out with respect to 237 drugs comprising 74 single plants, 62 Ayurvedic formulations, and 101 coded drugs.  A total of 75 research projects (71 Intra-Mural Research Projects & 04 Collaborative Research Projects) related to toxicity and efficacy studies have been completed.